Abstract
The purpose of this study was to assess the relationship between arterial stiffness, as measured by brachial-ankle pulse wave velocity (baPWV), and the presence of the metabolic syndrome (MS) in a Chinese population. A total of 4,445 subjects were enrolled. The prevalence of MS in our study population was 21.7%, 17.2% and 25.6% for the general population, males and females, respectively. With adjustments for age, gender, cigarette smoking, heart rate, total cholesterol, low-density lipoprotein (LDL) cholesterol, and the use of anti-hypertensive drug, the stepwise regression analysis showed that baPWV had a significant relationship with components of MS, including systolic blood pressure (P < 0.001), diastolic blood pressure (P < 0.001), glucose (P < 0.001), high-density lipoprotein (HDL) cholesterol (P = 0.04), and triglycerides (P < 0.001), but no relationship with waist circumference (P = 0.25). With an increase in the number of the MS components, baPWV increased significantly both in women and men. This study indicated that the MS is indeed a risk factor for arterial stiffness. Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease.
Highlights
Metabolic syndrome (MS) represents a clustering of several cardiovascular risk factors including abdominal obesity, impaired glucose intolerance, dyslipidemia, and hypertension[1,2]
The present study investigates the relationship between arterial stiffness, as measured by Brachial-ankle pulse wave velocity (baPWV), and the components of the MS in a Chinese population
Along with in-depth understanding of cardiovascular disease, people gradually realized that the structure and function of the vascular wall lesions are closely related to the development of cardiovascular disease
Summary
Metabolic syndrome (MS) represents a clustering of several cardiovascular risk factors including abdominal obesity, impaired glucose intolerance, dyslipidemia, and hypertension[1,2]. MS is associated with a marked increase in the risk of atherosclerotic cardiovascular disease. Arterial stiffness is a marker of arterial damage and its increase has been shown to be associated with an increased risk of cardiovascular events[6,7,8,9]. Brachial-ankle pulse wave velocity (baPWV) is an effective index of the arterial stiffness of large arteries and is widely used for noninvasive assessment of vascular function. The present study investigates the relationship between arterial stiffness, as measured by baPWV, and the components of the MS in a Chinese population
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