RELATIONSHIP BETWEEN BLOOD PRESSURE, BODY WEIGHT INDEX AND ANTHROPOMETRIC, METABOLIC-HORMONAL PARAMETERS IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION

Abstract

The aim of the study – to evaluate changes in clinical and laboratory parameters andto analyze the relationship between blood pressure (BP), body mass index (BMI) andanthropometric, metabolic and hormonal parameters in patients with essential arterialhypertension (EAH).Material and methods. 100 subjects with EAH and target- organ damaging (2nd stage),moderate, high, very high cardiovascular risk were involved in the case-control study.There were 70.84% females, 29.16% males, the mean age 57.86±7,81 years. The controlgroup consisted of 60 healthy individuals, who did not diff er by sex and age (p>0.05).Pearson’s χ2-test was used to establish the relationship between the parameters, in the caseof categorical variables; ANOVA variance analysis, if one of the variables is categorical
 and the other is numerical (interval), in the case of abnormal array distribution – non-parametric Kruskal- Wallis test.
 Results. The development and course of EAH is characterized by clinical- hemodynamicand metabolic disorders that are nonlinearly exacerbated with the severity of hypertension.ANOVA analysis showed that BP is directly related to age (F=7.46; p<0.001), bodyweight (F=4.32; p=0.048), height (F=5.60; p=0.04), waist circumference (WC) (F=7.61;p=0.043), as well as WC/HC (2
 =6.75; =0.004), glucose level (2
 =9.41; p=0.003),
 vitamin D and parathyroid hormone (PTH) (2
 =6.08; p=0.043 and 2
 = 19.34; p=0.013),respectively. Body mass index (BMI) is expected to be strongly associated with BP(2= 40.06; p<0.001), WC/HC (2
 =12.13; p=0.007), blood glucose and vitamin D
 (2=19.11; p<0.001 and 2
 16.12; p=0.001), bordering on heredity for cardiovascular
 diseases (2=7.72; p=0.052).Conclusions. BP is directly related to age, body weight, height, WC (F=4.32-7.46;p<0.048-0.001), as well as WC/HC, glucose level, vitamin D and PTH (2
 =6.08-19.34;
 р=0.043-0.003). BMI is strongly associated with WC (2
 =40.06; p<0.001), WC/HC
 (212.13; p = 0.007), blood glucose and vitamin D concentration (2
 = 19.11; p<0.001;
 2= 16.12; p = 0.001).