LINKAGE BETWEEN BLOOD PRESSURE, BODY MASS INDEX AND ANTHROPOMETRIC, METABOLIC, HORMONAL PARAMETERS IN PATIENTS WITH ESSENTIAL ARTERIAL HYPERTENSION

Abstract

Objective: The aim of the study was to evaluate changes in clinical and laboratory parameters and to analyze the linkage between blood pressure (BP), body mass index (BMI) and anthropometric, metabolic, hormonal parameters in patients with essential arterial hypertension (EAH). Design and method: 100 subjects with EAH and target-organ damaging (2nd stage), moderate, high, very high cardiovascular risk were involved in the case-control study. There were 70.84% females, 29.16% males, the mean age 57.86±7,81 yo. The control group consisted of 60 healthy individuals, that did not differ by sex and age (p>0.05). Pearson's ⇙2-test was used to establish the linkage between the parameters, in the case of categorical variables; ANOVA variance analysis, if one of the variables is categorical and the other is numerical (interval), in the case of abnormal array distribution – non-parametric Kruskal-Wallis's test. Results: The development and course of EAH is characterized by clinical, hemodynamic and metabolic disorders that are nonlinearly exacerbated with the severity of hypertension. ANOVA analysis showed that BP is directly related to age (F = 7.46; p<0.001), body weight (F = 4.32; p = 0.048), height (F = 5.60; p = 0.04), waist circumference (F = 7.61; p = 0.043), as well as Waist-Hip Ratio (⇙2 = 6.75; p = 0.004), glucose concentration (⇙2 = 9.41; p = 0.003), vitamin D and parathyroid hormone (PTH) (⇙2 = 6.08; p = 0.043 and ⇙2 = 19.34; p = 0.013), respectively. Body mass index (BMI) is expected to be strongly associated with BP (⇙2 = 40.06; p<0.001), Waist-Hip Ratio (⇙2 = 12.13; p = 0.007), blood glucose and vitamin D (⇙2 = 19.11; p<0.001 and ⇙2 = 16.12; p = 0.001), bordering on heredity for cardiovascular diseases (⇙2 = 7.72; p = 0.052). Conclusions: Blood pressure is directly related to age, body weight, height, WC (F = 4.32-7.46; p<0.048-0.001), as well as Waist-Hip Ratio, glucose level, vitamin D and PTH (⇙2 = 6.08-19.34; p = 0.043-0.003). BMI is strongly associated with WC (⇙2 = 40.06; p<0.001), Waist-Hip Ratio (⇙2 = 12.13; p = 0.007), blood glucose and vitamin D concentration (⇙2 = 19.11; p<0.001; ⇙2 = 16.12; p = 0.001).