Abstract
To determine the relationship between anterior segment and optic nerve head (ONH) parameters. Two hundred healthy subjects were enrolled in this study. The par-ticipants underwent measurement of anterior segment parameters with a Pentacam Scheimpflug system and imaging of the optic disc with confocal scanning laser ophthalmoscopy. Pearson's correlation coefficient was calculated to assess the associations between ONH and anterior segment parameters. Multivariate regression analyses controlling for age and disc area as confounding factors were also conducted. There were significant negative relationships between optic disc area and corneal thickness (p=0.03, r=-0.217) and volume (p=0.017, r=-0.239). Corneal refractive power was significantly correlated with cup area, rim area, rim volume, and cup/disc ratio (p<0.05 for all). An increase of 1 diopter in anterior corneal refractive power corresponded to a decrease of 0.022 in cup/disc ratio. Rim volume was negatively correlated with anterior chamber depth and anterior chamber volume (p<0.05 for both). A 1-mm3 increase in anterior chamber depth corresponded to a 0.154-mm3 decrease in rim volume. Mean and maximum cup depth measurements were not associated with any of the anterior segment parameters. In nonglaucomatous eyes, the dimensions and shape of the ONH may be related to anterior segment morphology. Therefore, it may be helpful to take anterior segment parameters into consideration in evaluating the OHN.
Highlights
Increasing attention is being focused on the impact of corneal parameters as potential determinants of the risk of glaucoma
Significant negative correlations were found between anterior chamber volume (ACV) and disc area (DA) (p=0.034, r=-0.150) and between anterior chamber depth (ACD) and DA (p=0.028, r=-0.156)
The thickness and biomechanical properties of the cornea have been of interest as important risk factors for the development of glaucomatous optic nerve damage[1,8,9,10]
Summary
Increasing attention is being focused on the impact of corneal parameters as potential determinants of the risk of glaucoma. Many studies have investigated the question of whether corneal thickness and/or biomechanical properties have an influence on glaucoma. The Ocular Hypertensive Treatment Study (OHTS) and the Early Manifest Glaucoma Treatment Study (EMGT) demonstrated a link between central corneal thickness (CCT) and the risk of glaucoma[1,2]. A morphological link is possible between aspects of the front of the eye and optic nerve head (ONH) parameters. Owing to the anatomic continuity of the cornea, sclera, and optic disc lamina, it can be hypothesized that corneal parameters may reflect parameters of the ONH, such as optic disc area (DA) and deformability of the lamina cribrosa. Corneal endothelium, and optic nerve lamina cribrosa differentiate from the neural crest, they are embryologically related to one another[4]
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