Analysis on thickness of retinal nerve fiber layer and optic nerve head parameters in myopia by using optical coherence tomography

Abstract

Objective To study the characteristics and clinical significance of retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) parameters along with an increase of myopia degree.Methods According to the myopic degree,110 subjects were divided into 4 groups:normal,slight,medium and high myopic groups.Optical coherence tomography (OCT) was used to measure the RNFL thickness and ONH parameters.Each subject had 3D scans on the ONH with 6× 6mm (512×128).The mean and different quadrants RNFL thickness and ONH parameters in different groups were analyzed.Results Compared with normal groups,the mean RNFL thicknesses in all myopic groups were significantly thinner.The change occurred first in nasal quadrant.RNFL thicknesses in high myopic groups were significantly thinner in nasal,inferior and superior quadrant.However,temporal quadrant was significantly thicker.Compared with normal groups,ONH parameters in every myopic group were smaller.Except Rim Area and Rim Volume,all parameters were significantly smaller.Conclusions The mean RNFL thickness in myopic groups is thinner and thinner along with an increase of myopia degree.Different from others,temporal quadrant is thicker.Except Rim Area and Rim Volume,all ONH parameters are significantly smaller.Above mentioned features have the clinical significance for diagnosing disease. Key words: Optical coherence tomography; Retinal nerve fiber layer thickness; Myopia