Abstract
The aim of this study was to analyze the association between the amount of daily movement measured with a triaxial accelerometer (MIMAMORI-Gait) and motor symptoms in patients with Parkinson’s disease (PD). The subjects were 50 consecutive patients with untreated PD free of dementia. The amount of overall movement over 24 h was measured with the portable MIMAMORI-Gait device and its association with the modified Hoehn and Yahr stage and UPDRS part II and III scores was analyzed. In patients with PD, the amount of overall movement measured with MIMAMORI-Gait was significantly associated with the UPDRS part II score (β = −0.506, p < 0.001) and part III score (β = −0.347, p = 0.010), but not with the modified Hoehn and Yahr stage. The amount of overall movement measured with MIMAMORI-Gait can potentially be used for evaluation of motor symptoms and ADL in PD patients.
Highlights
Parkinson’s disease (PD) is a typical neurodegenerative disorder characterized mainly by motor symptoms
The motor symptoms of PD vary according to the mental status of the patient and the surrounding environment at the time of assessment
Bradykinesia and gait disturbance greatly affect activities of daily living (ADL), some patients are less likely to recognize those symptoms compared with tremor [25]
Summary
Parkinson’s disease (PD) is a typical neurodegenerative disorder characterized mainly by motor symptoms. Treatment of PD requires adequate assessment of the status of patients as well as consideration of the effects of the disease on their daily lives and social activities. Several methods for assessment of PD motor symptoms are available, two are widely used in daily clinical practice—the Unified Parkinson’s Disease Rating Scale (UPDRS) [2]. The Movement Disorder Society-sponsored revision of UPDRS (MDS-UPDRS) [3]—which allow comprehensive assessment of motor symptoms and difficulties in activities of daily living (ADL). Evaluation by an expert in the examination room and assessment of the ADL based on patient self-reports have several limitations. The on–off state is often difficult to assess in routine clinical practice, especially in patients with motor fluctuations
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