Abstract
This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes. Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. Testosterone was determined by the radio-immunoassay whereas adiponectin levels were determined by enzyme-linked immunosorbent assay (ELISA). The average serum testosterone did not differ between the diabetes and the control group, but the average adiponectin in the diabetes group was lower (14.6 (14.2-15.0) vs. 24.3 (24.05-24.55) ng/mL, P = 0.001). In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P = 0.009). Univariate correlation analysis showed an inverse weak correlation between adiponectin and testosterone concentrations in male diabetic patients (r = -0.27, P = 0.009). There was no significant correlation between adiponectin and testosterone in female patients (r = -0.05, P = 0.167). We conclude that patients with type 2 diabetes have lower serum adiponectin concentration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics.
Highlights
This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes
The circulating concentrations of adiponectin are inversely proportional to adiposity, and low adiponectin concentrations predict the development of type 2 diabetes and cardiovascular disease [2]
Levels of adiponectin and testosterone according to gender in diabetes and control patient groups are presented in table 2
Summary
This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes. Serum adiponectin levels are influenced by several factors, such as age, sex, body mass index and diabetes [2,3,4,5] and are decreased in patients with type 2 diabetes mellitus or metabolic syndrome [5,6]. Serum and interstitial total adiponectin levels are lower than in lean subjects [7]. Serum and interstitial total adiponectin is reduced in both obese and lean men. Current biochemical and physiological evidence suggest that low adiponectin levels may be a consequence of insulin resistance with compensatory hyperinsulinemia [1]
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