Relationship among serum levels of suppressors of cytokine signaling-3, insulin-like growth factor binding protein-1 and hyperglycemia in critically ill children

Abstract

Objective To investigate the relationship among serum levels of suppressors of cytokine signaling-3(SOCS-3), insulin-like growth factor binding protein-1(IGFBP-1) and hyperglycemia in critically ill children. Methods The 64 critically ill children who suffered from sepsis, after surgical repair of congenital heart disease by extracorporeal circulation, and after surgery of severe traumatic from January 2009 to January 2012 in Department of Pediatric Intensive Care Unit(PICU) of Guangzhou Women and Children's Medical Center were selected as the research object. According to the blood glucose levels on admission, the 64 children were divided into the normal glucose group and the hyperglycemia group. The 15 cases of healthy children in the same period in Guangzhou Women and Children's Medical Center were selected as the healthy control group.The levels of blood glucose, insulin, SOCS-3, IGFBP-1 and insulin resistance index(HOMA-IR) were measured and compared among groups when they were on admission. Results (1) The blood glucose of the hyperglycemia group was significantly higher than those in the normal glucose group and the healthy control group[(9.83±2.48) mmol/L vs (4.82±0.76) mmol/L, (4.49±0.81) mmol/L](P 0.05). (4) The blood glucose was positively correlated with the insulin and HOMA-IR(r=0.455, 0.773, P 0.05). Conclusions In the critically ill children, hyperglycemia was related to the insulin resistance which can not be evaluated through changes in serum levels of SOCS-3 and IGFBP-1.In addition, it cannot be excluded that the critically ill children may have insulin resistance and pancreatic β-cell dysfunction simultaneously. Key words: Critical illness; Hyperglycemia; Suppressors of cytokine signaling-3; Insulin-like growth factor binding protein-1