Abstract
Renal fibrosis is the main cause leading to end-stage chronic kidney disease. Transforming growth factor - beta 1 (TGF-beta1) have a major role in the process of renal fibrosis. Objectives: To survey the relation of serum TGF beta1 level with: age, sex, BMI, blood pressure and glomerular filtration rate. Method: A cross-sectional study. Results: Levels of serum TGF-beta1; in patients <40 year old, 40-60 year old and > 60 year of age were respectively 39,97 ± 9,76 ng / ml; 36,07 ± 10,10 ng / ml and 38,29 ± 10,87 ng / ml, p> 0,05. In men and women were respectively 36,71 ± 9,12 ng / ml and 40,43 ± 10,54, p> 0,05. In patient group with BMI ≤ 23 and > 23 were respectively 37,95 ± 9,85 ng / ml and 37,58 ± 12,38, p > 0,05. Levels of serum TGF-beta1 positive correlated with systolic blood pressure index (r = 0,40; p < 0,01) and negative correlated with glomerular filtration rate (r = - 0,29; p <0,01). Conclusion: There are no difference of serum TGF-beta1 levels between men and women, between the age groups (<40 years, 40 to < 60 years and ≥ 60 years), between BMI groups < 23 and BMI group ≥ 23. Level of serum TGF-beta1 positive correlated with systolic blood pressure index and negative correlated with glomerular filtration.vKey words: TGF-beta1, chronic kidney disease
Published Version
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