RELATION OF PERIAORTIC ADIPOSE TISSUE WITH PARAMETERS OF METABOLIC SYNDROME IN YOUNG PEOPLE WITH ABDOMINAL OBESITY

Abstract

Objective: The main aim of study was to investigate the association between periaortic fat (PF) and metabolic parameters, subcutaneous (SF), visceral (VF), epicardial (EF) fat in patients with abdominal obesity (AO). Design and method: 127 patients 18–45 y.o. (average age 38,4 ± 6,0) with AO (men (M) – 58,3%) were enrolled in study. Height, weight, BMI, waist circumference, blood tests (fast glucose (FG),glucose tolerance (GT), insulin, HOMA-IR, lipid profile) were measured. MS was defined as AO (cut-off of > 80 cm in women (W) and > 94 cm in M) plus > 1 sign: HDL < 1,30 (w)/1,04(m)mmol/l; triglycerides > 1,7mmol/l; FG > 5,6mmol/l; violation GT; BP > 140/90mmHg. SF, VF, PF, EF (range: -150 to -30 HU) was measured by computed tomography. We calculated ratio subcutaneous to visceral fat (RSV). 24 hour blood pressure monitoring was performed. We formed 2 groups: AO (AO plus 1 or less sing of MS) and MS. Results: Tab. 1. Correlations PF with sex r = 0,223 (p = 0,009), with BMI r = 0,347 (p = 0,000), with WC r = 0,525 (p = 0,000), with uric acid r = 0,425 (p = 0,000), FG r = 0,27 (p = 0,002), insulin level r = 0,40 (p = 0,000), with HOMA r = 0,41 (p = 0,000), TG r = 0,32 (p = 0,000), HDL r = -0,37 (p = 0,000), LDL r = 0,23 (p = 0,005), with VF r = 0,55 (p = 0,000), SF r = 0,31 (p = 0,000), EF r = 0,69 (p = 0,000), RSV r = -0,300 (p = 0,000) were found. Conclusions: PF are directly related to most of metabolically parameters. PF in people with abdominal obesity is involved in metabolic syndrome.