RELAÇÃO DO DIABETES MELLITUS TIPO II COM A DEPRESSÃO E O TRATAMENTO COM ANTIDEPRESSIVOS

Abstract

The association between type 2 diabetes mellitus (DM2) and the presence of depression has been presented in the literature by several authors, the apparent symptoms related to hyperglycemia, such as excessive tiredness and weakness may have positive points for the onset of depressive symptoms, as well as responsibility for treatment, dietary restrictions and adverse effects in the use of antidepressant drugs. Among those that stand out as risk factors commonly associated with the development of depressive symptoms in patients with diabetes are: age, obesity, as well as the increase in the amount of drugs in use, such as antidepressants. Thus, this study is a systematic review, and seeks to better understand the relationship between diabetes mellitus and depression and the possible implications of the use of antidepressants on metabolic changes, specifically, glycemic level. Through the analyzed articles, it can be considered that there is a relationship between diabetes mellitus and an increase in clinical depressive symptoms. This relationship covers both metabolic control and adaptive aspects, such as socioeconomic factors, non-acceptance of the disease, low educational level, lifestyle, family history. Antidepressants of the selective serotonin reuptake inhibitor (SSRI) class have been shown to have a positive effect on the treatment of depression in patients with DM2. The most studied antidepressants in this class were Sertraline and Fluoxetine and they were effective in treating depression and improving glycemic control.