Regulatory effects of miRNAs targeting PI3K/AKT signaling pathway in the pathogenesis of lung cancer

Abstract

In the contemporary world, lung cancer has become the most frequent type of cancer in humankind. Recent studies revealed that lung cancer proliferation is correlated with microRNA (miRNA) dysregulation. Several studies have identified PI3K/AKT signaling pathway as the key target of certain miRNAs and play a fundamental role in cellular activities involved in lung cancer cell invasion and metastasis. For lung cancer research, miRNAs and their interrelated target genes could be a capable novel field in its diagnosis as well as in therapy. This review highlights the role of regulatory miRNAs targeting the PI3K/AKT signaling pathway in lung carcinogenesis.