Abstract
Objectives: B-lymphocytes have critical roles in the inflammatory process that drives atherosclerosis. In animal models, conventional B2 B cells promote atherosclerosis, whilst innate B1a B cells are protective. B cells with regulatory function (Bregs) have been identified in animals and humans and have been implicated in the pathogenesis of autoimmunity. Whether Bregs have a role in human atherosclerosis is currently unknown. Our aim was to characterise the frequency, phenotype and function of Bregs in atherosclerosis patients.
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