Abstract
Regulation of Tissue Responses: The TWEAK/Fn14 Pathway and Other TNF/TNFR Superfamily Members That Activate Non-Canonical NFκB Signaling.
Highlights
The TWEAK/Fn14 pathway as an injury-inducible mediator of pleiotropic responses is introduced in a review of the work implicating sustained Fn14 signaling in disease pathogenesis and encompassing the current TWEAK/Fn14-targeting approaches for treatment of human disease [2]
Broad relevance to neurological diseases is supported by a basic TWEAK/Fn14 role in regulating the structure and function of the neurovascular unit, thereby regulating blood–brain barrier (BBB) permeability [3]
Relevant to lupus is the pathogenic role of TWEAK/Fn14 in the renal manifestation of lupus nephritis
Summary
The TWEAK/Fn14 pathway as an injury-inducible mediator of pleiotropic responses is introduced in a review of the work implicating sustained Fn14 signaling in disease pathogenesis and encompassing the current TWEAK/Fn14-targeting approaches for treatment of human disease [2]. Evidence supporting TWEAK/Fn14-mediated pathological mechanisms in contexts of acute kidney injury and chronic kidney diseases is substantial and clinical targeting of TWEAK is ongoing in lupus nephritis [5].
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