Abstract
This chapter discusses the regulation of the synthesis of extracellular proteinases in bacilli. Extracellular proteinases synthesized by bacilli mostly belong to two groups of enzymes: (1) metalloenzymes and (2) serine enzymes. The following types of regulation are assumed to control the synthesis of proteinases in bacilli: (1) catabolite repression, (2) suppression by growth and derepression in the stationary phase, (3) triggering and subsequent switching off by the developmental mechanisms during sporogenesis, and (4) repression by amino acids. Proteinase is formed preferentially during growth in poor media. Simultaneous presence of a readily metabolizable carbon source and of amino acids is necessary for an efficient repression. Higher temperature also suppresses the formation of the enzyme. The synthesis of the proteinase by sporulating cells is partially under a developmental control and is switched off at later stages of sporogenesis.
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