Abstract
Rat splenocytes are shown to contain a population of plastic adherent, iron ingesting cells, presumably macrophages, which mediate suppression of concanavalin A-induced blastogenesis. A subpopulation of splenocytes which are separable from responding cells and suppressor macrophages by density gradient techniques has been obtained which negate the suppressive effects of macrophages. These cells, which appear to be a mature T-cell population, regulate the suppressive effects mediated by macrophages and are termed contrasuppressor cells.
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