Abstract
Regulation of sterol synthesis in 15 tissues of rat. II. Role of rat and human high and low density plasma lipoproteins and of rat chylomicron remnants.
Highlights
Medicine, The University of Texas Health Science Center at Dallas, These studies were undertaken to identify which, if any, of the circulating lipoproteins regulates sterol synthesis in various extrahepatic organ systems
With a similar experimental protocol, the infusion of low density lipoproteins (LDL) suppressed synthesis in most of the tissues tested, whereas infusion of high density lipoproteins (HDL) or chylomicron remnants had no suppressive effect on synthesis in this group of tissues
In the preceding paper
Summary
AND OF RAT (Received for publication, November 8, 1976, and in revised form, January 24, 1977). On the basis of these studies and other published reports, three functionally different types of lipoprotein feedback regulation of sterol synthesis are proposed: (a) regulation of hepatic cholesterogenesis by chylomicron remnants; (b) regulation of sterol synthesis in a number of nonendocrine, extrahepatic tissues by LDL; and (c) regulation of sterol synthesis in ovary and adrenal gland principally by HDL. In recent publications from this department, it has been reported that, coincident with this fall in the concentration of plasma cholesterol, the rate of cholesterol synthesis markedly increases in a number of extrahepatic tissues, suggesting that sterol synthesis in these tissues normally is suppressed by one of the plasma lipoprotein fractions [7,8,9]. The recipient animals were first treated with APP to lower markedly their level of endogenous circulating lipoproteins, following which varying amounts of rat and human low and high density lipoproteins and rat chylomicron remnants were infused intravenously for 40 h. On the basis of these studies, we propose that there are at least three different types of lipoprotein regulation of sterol synthesis in the various tissues of the body
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