Abstract
This chapter discusses the regulatory aspects of primary pathways for methanol metabolism in methylotrophic yeasts. Among assimilatory enzymes, dihydroxyacetone synthase and dihydroxyacetone kinase are most important in view of regulation. When considering the control of the distribution of a formaldehyde flux into oxidative and assimilatory pathways, attention should be focused on two main factors: (1) the effect of GSH on the activity of formaldehyde dehydrogenase and dihydroxyacetone synthase and (2) the balance of energy equivalents in primary pathways of methanol oxidation and assimilation. Energetic balance of formaldehyde oxidation and assimilation in methylotrophic yeasts is controlled by GSH at the level of formaldehyde dehydrogenase and dihydroxyacetone synthase and/or by the ratio of NADH and ADP formed at the levels of formaldehyde dehydrogenase and dihydroxyacetone kinase, respectively.
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