Abstract
The vitreous gel consumes oxygen in an acellular, ascorbate-dependent manner. The function of this biophysical property of the vitreous gel is to tightly regulate intraocular oxygen tension so that the vascular structures of the eye are highly oxygenated while the adjacent avascular structures are kept in a hypoxic environment, thought necessary for the health of the eye. A gel vitreous contains more ascorbate and consumes more oxygen than vitreous that has undergone age-related liquefaction or surgical removal. As the vitreous gel liquefies or is removed surgically, it loses its ability to consume oxygen, leading to disease states characterized by excess oxygen and oxidation-induced tissue damage.
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