Regulation of Human Epidermal Stem Cell Proliferation and Senescence Requires Polycomb- Dependent and -Independent Functions of Cbx4

Abstract

(Cell Stem Cell 9, 233–246; September 2, 2011) Luca Cozzuto was omitted from the original author list by mistake. Dr. Cozzuto performed the analysis of the ChIP-seq of Cbx4 in human epidermal keratinocytes included in this work. The updated author list is both provided above and is as follows: Luis, N.M., Morey, L., Mejetta, S., Pascual, G., Janich, P., Kuebler, B., Cozzuto, L., Roma, G., Nascimento, E., Frye, M., Di Croce, L., and Benitah, S.A. We apologize for this confusion. Regulation of Human Epidermal Stem Cell Proliferation and Senescence Requires Polycomb- Dependent and -Independent Functions of Cbx4Luis et al.Cell Stem CellSeptember 02, 2011In BriefHuman epidermal stem cells transit from a slow cycling to an actively proliferating state to contribute to homeostasis. Both stem cell states differ in their cell cycle profiles but must remain guarded from differentiation and senescence. Here we show that Cbx4, a Polycomb Repressive Complex 1 (PRC1)-associated protein, maintains human epidermal stem cells as slow-cycling and undifferentiated, while protecting them from senescence. Interestingly, abrogating the polycomb activity of Cbx4 impairs its antisenescent function without affecting stem cell differentiation, indicating that differentiation and senescence are independent processes in human epidermis. Full-Text PDF Open Archive