Abstract
The serine/threonine protein kinase GSK3 is a key component of the Wnt signalling cascade that controls cell-fate decisions in metazoans. Binding of Wnt to the Frizzled serpentine receptors inhibits GSK3 activity, causing cytoplasmic β-catenin to accumulate and be translocated to the nucleus to alter gene transcription. GSK3 is often perceived to be constitutively active or to have a basal kinase activity; however, maximal GSK3 activity requires the phosphorylation of a conserved GSK3 tyrosine residue. A recent study 1 Kim L. et al. The novel tyrosine kinase ZAK1 activates GSK3 to direct cell fate specification. Cell. 1999; 99: 399-408 Abstract Full Text Full Text PDF PubMed Scopus (149) Google Scholar has shed light on this activation of the GSK3 pathway.
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