Abstract
An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs. During Drosophila larval development, hematopoietic sites are in direct contact with sensory neuron clusters of the peripheral nervous system (PNS), and blood cells (hemocytes) require the PNS for their survival and recruitment to these microenvironments, known as Hematopoietic Pockets. Here we report that Activin-β, a TGF-β family ligand, is expressed by sensory neurons of the PNS and regulates the proliferation and adhesion of hemocytes. These hemocyte responses depend on PNS activity, as shown by agonist treatment and transient silencing of sensory neurons. Activin-β has a key role in this regulation, which is apparent from reporter expression and mutant analyses. This mechanism of local sensory neurons controlling blood cell adaptation invites evolutionary parallels with vertebrate hematopoietic progenitors and the independent myeloid system of tissue macrophages, whose regulation by local microenvironments remain undefined.
Highlights
An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs
Based on their functional dependence on sensory neurons of the Hematopoietic Pockets (HPs) for their localization and survival, and the elevated proliferation of resident hemocytes compared to those in circulation[4], we investigated the molecular mechanism of hemocyte induction by the sensory neurons of the peripheral nervous system (PNS)
First we examined the local anatomy of PNS neurons and resident hemocytes
Summary
An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs. Activin-b has a key role in this regulation, which is apparent from reporter expression and mutant analyses This mechanism of local sensory neurons controlling blood cell adaptation invites evolutionary parallels with vertebrate hematopoietic progenitors and the independent myeloid system of tissue macrophages, whose regulation by local microenvironments remain undefined. Actb plays a key role in this regulation, as evidenced by the induction of Actb expression in response to PNS activity, and a blunted response in Actb mutants These findings shed new light on the mechanisms by which local microenvironments regulate blood cell adaptation and may integrate sensory inputs
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