Abstract
Publisher Summary This chapter discusses the major biochemical and subcellular characteristics of the systems that regulate cholesterol synthesis in the liver and in the intestine. The rate of cholesterol synthesis in the livers of higher animals is controlled primarily by a sensitive negative feedback system, and to a lesser extent, by caloric intake. Bile acids do not play a direct role in regulation of cholesterol synthesis in the liver. Cholesterol synthesis in the intestine of higher animals has been shown to be controlled by a similar feedback control mechanism; however, the feedback inhibitor consists of bile acids rather than cholesterol. Phylogenetic studies indicate that, in contrast to the case in higher animals, in nonmammalian vertebrates, cholesterol synthesis in the intestine is regulated by cholesterol itself. The most striking defect in the control of cholesterol synthesis so far observed involves the consistent loss of the cholesterol feedback system in all hepatomas.
Published Version
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