Abstract
Natural product research is a cornerstone of the architectural framework of clinical medicine. Berbamine is a natural, potent, pharmacologically active biomolecule isolated from Berberis amurensis. Berbamine has been shown to modulate different oncogenic cell-signaling pathways in different cancers. In this review, we comprehensively analyze how berbamine modulates deregulated pathways (JAK/STAT, CAMKII/c-Myc) in various cancers. We systematically analyze how berbamine induces activation of the TGF/SMAD pathway for the effective inhibition of cancer progression. We also summarize different nanotechnological strategies currently being used for proficient delivery of berbamine to the target sites. Berbamine has also been reported to demonstrate potent anti-cancer and anti-metastatic effects in tumor-bearing mice. The regulation of non-coding RNAs by berbamine is insufficiently studied, and future studies must converge on the identification of target non-coding RNAs. A better understanding of the regulatory role of berbamine in the modulation of non-coding RNAs and cell-signaling pathways will be advantageous in the effective translation of laboratory findings to clinically effective therapeutics.
Highlights
The deregulation of cell-signaling pathways is a central area of research in molecular oncology, and scientists have developed a nearly complete resolution of the multiple signaling cascades in different cancers
We have systematically analyzed how berbamine induces the activation of the TGF/SMAD pathway for the effective inhibition of carcinogenesis
Regulation of TGF/SMAD Pathway Berbamine and radiation markedly reduced the levels of p-STAT3 in FaDu cells
Summary
The deregulation of cell-signaling pathways is a central area of research in molecular oncology, and scientists have developed a nearly complete resolution of the multiple signaling cascades in different cancers. JAK/STAT and CAMKII/c-Myc are central drivers of carcinogenesis and metastasis. Nature has evolved over billions of years to generate an extra-ordinarily diverse array of natural products of wider structural variations and incredible complexities. Such widely heralded landmark discoveries as etoposide, teniposide, vinblastine and vincristine serve as monuments to the contributions of medicinal chemistry research over the decades. A comprehensive overview of the regulation of signaling pathways by berbamine in carcinogenesis and metastasis has not yet been explored, which can underscore and identify the existing knowledge gaps in this field. We browsed PUBMED, using the keywords berbamine, cancer and metastasis In this mini-review, we comprehensively analyze how berbamine modulates deregulated pathways (JAK/STAT, CAMKII/c-Myc) in various cancers. We have systematically analyzed how berbamine induces the activation of the TGF/SMAD pathway for the effective inhibition of carcinogenesis
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
