Abstract
The intraventricular administration of 6-hydroxydopamine (6-OHDA) to adult rats or its subcutaneous administration to newborns leads to an increase in the density of β-adrenergic receptors with no change in their properties. The administration of inhibitors of norepinephrine (NE) uptake or metabolism or the incubation of slices of rat cerebral cortex with isoproterenol (ISO) leads to an apparent loss of receptors. The pharmacological specificity of β-adrenergic receptors in rat cerebral cortex suggests that both β-1 and β-2-adrenergic receptors are present. The chronic administration of 6-OHDA or desemethylimipramine (DMI) cause changes in the density of β-1 receptors without affecting the density of β-2 receptors.
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