Abstract
Previous studies have shown that pulse (or legume) consumption can improve lipid and glucose control, and there is emerging evidence that pulses may improve peripheral vascular function. It is unclear whether cerebral blood vessel function can also be improved. The aim of the present study was to determine whether regular consumption of pulses could improve cerebrovascular vasodilator responsiveness in older, overweight adults. Sixty‐eight adults (64.6 6.7 years, BMI 31.2 4.0 kg/m2) who were habitually low pulse consumers (i.e. 蠄 ½ cup of pulses per week) were randomized to incorporate pulse‐enriched foods (~100g/day [i.e. ¾ cup/day] pulses) or energy‐matched control foods into their usual diet for 12 weeks. Cerebral vasodilator responsiveness (CVR) was assessed by transcranial Doppler ultrasonography in response to acute hypercapnia (5%CO2 inhalation) at baseline, 6 and 12 Weeks. Five‐day weighed food records captured dietary data at baseline (prior to commencing) and Week 12. Pulse intake increased significantly in the Pulse vs Control group by Week 12 (115 33g vs. 3 8g, respectively P<0.001). CVR did not change by Week 12 in either group (Pulse: 0.89% 7.7, Control 3.6% 10.6, P>0.31). Regular pulse consumption does not appear to influence cerebrovascular vasodilator responsiveness. More sensitive methods may be required to detect changes in cerebrovascular health.Grant Funding Source: Grain Research Development Corporation
Published Version
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