Abstract
Experiments were performed on six batches (Batches I ∼ VI) of inbred Wistar rats with Walker-236 carcinosarcoma. The groups received, respectively, photodynamic therapy on its own (PDT, Batch I); perfusion of tumour infiltrating lymphocytes on its own (TIL, Batch II); or both of the above in conjunction therapy (PDT+TIL-A, Batch III; PDT+TIL-B, Batch IV: and PDT+TIL-AB, Batch V); and one control batch (Batch VI, which was injected with Hank’s buffered salt solution) which consisted of animals with untreated Walker-256 tumours. The results were as follows: the individual treatment (PDT, TIL) gave survival rates between 28.6% ∼ 49.8%, the cure rates ranging from 19.0% ∼ 28.2% The “combined” therapy in multiple doses increased significantlythe survival of tumour-bearing rats (84.7%) as well as the highest incidence of complete regression (65.3%). Cell-mediated immunity test values in Batches III-V exposed to multiple PDT+TIL doses showed higher values as compared to the values noticed in Batches I-II and the control Batch VI at 14, 28 and 42 days post-treatment. Summing up, this work demonstrates that “combined” photodynamic therapy with TIL immunotherapy stimulates cell-mediated antitumoural activity, produces modifications in tumour histological structure, increases survival rate and reduces tumoural incidence in Walker-256 carcinosarcoma in the rat model.
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