Regioselective Ring Opening of Epoxide with Alcohols: A Selective Route to α‐Alkylated Ketones and β‐Alkylated Secondary Alcohols

Abstract

AbstractHerein, we demonstrated an effective protocol for the regioselective ring opening of epoxides with alcohols. By following this strategy, both α‐alkylated ketones and β‐alkylated secondary alcohols were selectively obtained by changing the reaction parameters. Compared to the previously reported protocols, this methodology was operated using considerably lower base at lower temperature. Notably, a wide array of substrates with tolerance of different functional groups was demonstrated. A series of control experiments and deuterium‐labelling experiments were performed to understand this catalytic process.