Regioselective Cleavage of Unstrained CC Bond and CH Bond: Palladium–Copper Catalyzed Deacetophenonylative Arylation of Coumarin Derivatives

Abstract

AbstractA CαCβ bond activation of the carbonyl group in unstrained ketones catalyzed cooperatively by palladium and copper(II) with the departure of the acetophenone has been developed, and the subsequent coupling with a variety of aromatics via the formal CH activation similar to the Friedel–Crafts reaction affords the skeleton‐reconstructed coumarin derivatives with high regioselectivity.