Regioselective C−S Bond Formation between Flavones and Arylsulfonyl Chlorides through the Use of Ammonium Iodide

Abstract

AbstractA novel and regioselective ammonium iodide mediated C−S bond formation protocol involving flavones and sulfonyl chlorides to generate different ArS‐substituted flavone derivatives in high yields was developed. Different from existing metal‐free C−S bond formation protocols with the use of PPh3 or I2 as the catalyst, this method provides an alternative way of constructing C−S bonds through the use of NH4I as a catalyst, which makes it highly valuable for the efficient synthesis of thioether compounds.