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Abstract
The membrane bound guanylyl cyclase (GC) photoreceptor membrane GC1 (ROS-GC1) of photoreceptor cells synthesizes cGMP, the intracellular transmitter of vertebrate phototransduction. The activity of ROS-GC1 is controlled by small Ca 2+-binding proteins, named GC-activating proteins (GCAPs). We identified and characterized two short regulatory regions (M445–L456 and L503–I522) in the juxtamembrane domain (JMD) of ROS-GC1 by peptide competition and mutagenesis studies. Both regions are critical for the activation of ROS-GC1 by GCAP-1.
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