Regional specificity in Th2 cytokine-induced alterations in murine small intestinal and colonic smooth muscle function

Abstract

3 / 16, and velocity: 2 / 16). Both groups contained patients in whom patterns of motor abnormalities were comparable, and suggestive of a neuropathological process: ASTC: 4 normal, 3 (43%) abnormal; ISTC: 6 normal,3 (33%) abnormal. A generalised pattern of colonic transit delay and coexistent abnormalities of rectal sensorimotor function were frequent. Conclusions: Upper gastrointestinal and pan-colonic motility disturbances do exist in patients whose symptoms of intractable constipation were acquired following pelvic surgery or childbirth. Whether this effect is reflex mediated (e.g. recto-intestinal) cannot be answered by this study.