Abstract
Letters6 November 2001Regional Osteoporosis in Anorexia NervosaSteven Grinspoon, MD and Anne Klibanski, MDSteven Grinspoon, MDHarvard Medical School; Boston, MA 02114 (Grinspoon, Klibanski)Search for more papers by this author and Anne Klibanski, MDHarvard Medical School; Boston, MA 02114 (Grinspoon, Klibanski)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-135-9-200111060-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:We agree with Dr. Mehler's comments. We have previously shown that leptin levels are tightly regulated by adipose tissue in women with the restricting subtype of anorexia nervosa (1). Recently, Ducy and colleagues (2) demonstrated that leptin itself may inhibit bone formation through central mechanisms in leptin-deficient and wild-type mice. In women with anorexia nervosa, we have found that low leptin levels are associated with osteopenia and osteoporosis (1). Therefore, we believe that in this population, leptin is more likely to be a marker of fat loss and generalized undernutrition than a determinant of bone density. We agree ...
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