Regional myocardial edema detected by T2 mapping is a feature of cardiotoxicity in breast cancer patients receiving sequential therapy with anthracyclines and trastuzumab

Paaladinesh Thavendiranathan,Narinder Paul,Andrew Crean,Bernd J Wintersperger,Philippe Bedard,Eitan Amir,Elsie T Nguyen

doi:10.1186/1532-429x-16-s1-p273

Paaladinesh Thavendiranathan, Narinder Paul + Show 5 more

Open Access

https://doi.org/10.1186/1532-429x-16-s1-p273

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Abstract

Background Cardiotoxicity from cancer chemotherapy is an important cause of morbidity and mortality in breast cancer survivors. Left ventricular (LV) systolic dysfunction due to sequential use of anthracyclines and trastuzumab has been reported in up to 20-25% of patients. The pathophysiological changes associated with LV dysfunction have not been described non-invasively. We performed cardiac MRI (cardiac MR) with T2 mapping to assess whether myocardial edema is a feature of acute cardiotoxicity in women with breast cancer receiving sequential anthracyclines and trastuzumab.

Highlights

Cardiotoxicity from cancer chemotherapy is an important cause of morbidity and mortality in breast cancer survivors
We performed cardiac MRI with T2 mapping to assess whether myocardial edema is a feature of acute cardiotoxicity in women with breast cancer receiving sequential anthracyclines and trastuzumab
We prospectively recruited women with HER2+ breast cancer scheduled to receive anthracyclines followed by trastuzumab (Grp A) and patients during therapy with anthracyclines and trastuzumab who were diagnosed with subclinical cardiac toxicity (Grp B) using multi-gated acquisition scans (MUGA) based on Cardiac Review and Evaluation Committee’s criteria

Summary

Introduction

Cardiotoxicity from cancer chemotherapy is an important cause of morbidity and mortality in breast cancer survivors. Left ventricular (LV) systolic dysfunction due to sequential use of anthracyclines and trastuzumab has been reported in up to 20-25% of patients. The pathophysiological changes associated with LV dysfunction have not been described non-invasively. We performed cardiac MRI (cardiac MR) with T2 mapping to assess whether myocardial edema is a feature of acute cardiotoxicity in women with breast cancer receiving sequential anthracyclines and trastuzumab

Methods

Results

Conclusion