Regional monitoring of the urinary tract infections causative agents antibiotic resistance in the child population of the Chernivtsi region

V V Bezruk,S O Sokolnyk,A I Kovtun,O S Godovanets,L V Stegnitska,T О Bezruk,V V Maksymyuk,O I Godovanets,M I Sheremet

doi:10.14739/2310-1210.2017.6.115088

V V Bezruk, S O Sokolnyk + Show 7 more

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https://doi.org/10.14739/2310-1210.2017.6.115088

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Abstract

In the scope of current medical practice the “viewpoint” regarding the growth of antibiotic resistance of microorganisms is a threat to national security. A reasonable use of antibiotics on the basis of uropathogen regional bacterial sensitivity gives the opportunity to “restrain” the growth of antibiotic resistance of microorganisms and increase the effectiveness of the UTI treatment.The aim of the article is to determine the range and dynamics of the antibiotic resistance of major groups of infectious-inflammatory diseases causative agents of the urinary tract in the child population of the Chernivtsi region.Materials and methods. The analysis of etiologic spectrum and antibiotic resistance of uropathogens was conducted and observed in the urine samples of 657 patients who were provided with a specialized medical care in the Nephrology department of the “Municipal Children’s Clinical Hospital”, Chernivtsi (2014–2015) with the purpose of the dynamic control of possible changes in the regional antibiotic resistance of pathogens of causative pathogens of the “urinary tract infections” (UTI); identify the age and gender differences of the child population of the Chernivtsi region (2014–2015) compared to the monitoring data for the period of 2009–2013.Results. When UTI among of the child population of the Chernivtsi region leading etiologic organisms include strains of the family Enterobacteriaceae and uropathogen of the genus Proteus. A “wave-like” curve of the dynamics of antibiotic resistance of Enterobacteriaceae uropathogens with a decreasing tendency to the “drugs of choice” was observed among the child population of the region (2009–2015): penicillin (p < 0.01), cephalosporin II–III generation (p < 0.01) and medicine of the fluoroquinolone series (p < 0.01). A “wave-like” curve of the dynamics of antibiotic resistance of Proteus uropathogens with a decreasing tendency to the “drugs of choice” was observed among the child population of the region (2009–2015): semi-synthetic penicillin (p < 0.1), and medicine of the tetracycline series (p < 0.01).Conclusions. Regional microbiological monitoring of the uropathogens is an effective “tool” in higher quality treatment of infectious and inflammatory diseases of the urinary tract of the child population.

Highlights

In the scope of current medical practice the “viewpoint” regarding the growth of antibiotic resistance of microorganisms is a threat to national security
The analysis of etiologic spectrum and antibiotic resistance of uropathogens was conducted and observed in the urine samples of 657 patients who were provided with a specialized medical care in the Nephrology department of the “Municipal Children’s Clinical Hospital”, Chernivtsi (2014–2015) with the purpose of the dynamic control of possible changes in the regional antibiotic resistance of pathogens of causative pathogens of the “urinary tract infections” (UTI); identify the age and gender differences of the child population of the Chernivtsi region (2014–2015) compared to the monitoring data for the period of 2009–2013
The monitoring results for the period of 2009–2013 years [1,2,3] and obtained data of 2014–2015 observation years state that strains of the family Enterobacteriaceae prevail in microbial “landscape” in the child urine of the region; at the same time, it is worth to draw the attention to differences considering antibiotic sensitivity in UTI and non-infectious diseases of the urinary tract (Fig. 1)