Abstract
Background. According to statistical data from the WHO and a number of researchers, up to 40% of the world's population. Assessing the impact of the exposome in the population of the Russian Federation is a crucial issue of national public health care, the solution of which will provide a personalised approach to the treatment and prevention of allergic diseases in the local population. The aim of this study was to evaluate the sensitisation profile in children with allergic diseases from different regions of Russia. Methods. The study included sick children with allergic manifestations from different regions of the Russian Federation. A separate group consisted of children from the Far North regions from 2 to 12 years of age. The concentration of total IgE and allergen-specific immunoglobulins in blood was determined retrospectively on the basis of analyses of results obtained in CDCs performing immunoblotting tests using the Allergy-Q test system. Results. It was found that in more than 60% of cases allergic reactions are represented by combined manifestations. Allergic rhinitis took the second place, up to 65.32% of cases. Atopic dermatitis in the structure of allergic diseases took the third place, which was about 22,06%. The diagnosis of allergic conjunctivitis in our study was established in 15.38% of cases. Less than 5% in the structure of allergies was occupied by urticaria. In the group of household allergens the first place is occupied by cat, then dog and already then house dust. Among respiratory allergens, birch and/or other trees, weeds and mugwort are the leaders. Food sensitisation in children is mainly to milk, egg, fish and seafood. Conclusion. The peculiarities of sensitisation revealed in different regions are easily explained by the formed exposomes. The obtained data can be used to develop measures of prevention, diagnosis and treatment of allergic diseases.
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