Abstract
The effect of ethanolamine- O-sulphate induced elevation of cerebral GABA concentrations on monoamine and their metabolites levels has been studied in various regions of the rat brain. Increased GABA concentrations were associated with a decrease in turnover of dopamine in limbic regions: striatal dopamine was not significantly affected. An increased turnover of 5-hydroxytryptamine was also observed in other brain areas. Increased cerebral GABA concentrations had no effect on regional noradrenaline turnover. The possible sites of interaction between the neurotransmitters are discussed.
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