Abstract
Widespread use of surgical interventions in the abdomen of dogs determines the relevance of the study. The research tested the influence of therapeutic epidural blockade with 0.2% bupivacaine after surgical interventions on the background of potentiated local anaesthesia on the body of clinically healthy dogs undergoing ovariohysterectomy. In the control group postoperative analgesia was performed with the nonsteroidal anti-inflammatory drug rimadyl on the background of potentiated thiopental anaesthesia. Wound healing rates were determined in 10 animals of both control and experimental groups; blood counts and the level of inflammatory response were indicated in 5 animals of each group. The dynamics of reparative processes and complete wound healing in dogs of the experimental group occurred earlier than in animals of the control group, which confirmed the fact that the use of bupivacaine had a beneficial effect on tissue regeneration. The results of morphological and biochemical parameters of blood in animals of the experimental group manifested only an increase of leukocytes by 1.58 times, fibrinogen by 2.02 times, while in dogs of the control group the level of erythrocytes, haemoglobin and hematocrit decreased, leukocytes increased by 1.74 times, platelets decreased by 2.87 times and fibrinogen increased by 1.72 times. Among the stress response markers in the control group there was a 1.94 times increase in glucose level after surgery. In the experimental group there was a decrease in the intensity of the inflammatory reaction in dogs, accompanied by an increase of anti-inflammatory interleukin 4 (IL-4) only on the seventh day – 1.86 times, while in the control group the level of anti-inflammatory interleukin 1 receptor antagonist (IL-1RA) after three days increased by 2.30 times, after seven days – by 2.48 times, and the level of proinflammatory interleukin 6 (IL-6) after surgery increased by 2.57 times. It will be promising to conduct further research on the influence of therapeutic blockades with bupivacaine in animals in cases of various surgical interventions and pathological conditions, which will lead to faster recovery of animals and alleviate pathological processes.
Highlights
Pain management in veterinary patients is a crucial component of appropriate patient care (Grubb & Lobprise, 2020)
There is a number of innovative approaches that can improve the anaesthesiological support of surgical care, such as: the ability of local anaesthetics to cause analgesia and autonomic blockade, postoperative analgesia, repeated administration of the drug along with nerve structures
The research compared the effect of therapeutic epidural blockade with 0.2% solution of bupivacaine and traditional methods of medication influence, studied clinical and biochemical parameters of blood to determine the nature of inflammatory and stress reactions, as well as the dynamics of metabolism and wound healing in clinically healthy dogs undergoing ovariohysterectomy
Summary
Pain management in veterinary patients is a crucial component of appropriate patient care (Grubb & Lobprise, 2020). The use of local anaesthetic in certain doses may cause systemic toxicity, which must be indicated for different medicines. Due to their ability to profoundly decrease both intraoperative nociception and postoperative pain, local anaesthetic drugs are recommended for use in the majority of surgical procedures and traumatic injuries, as outlined in recent veterinary pain management guidelines (Epstein et al, 2015). There is a number of innovative approaches that can improve the anaesthesiological support of surgical care, such as: the ability of local anaesthetics to cause analgesia and autonomic blockade, postoperative analgesia, repeated administration of the drug along with nerve structures
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