Abstract
Bruch's membrane opening (BMO) is an important biomarker in the progression of glaucoma. Bruch's membrane opening minimum rim width (BMO-MRW), cup-to-disc ratio in spectral domain optical coherence tomography (SD-OCT) and lamina cribrosa depth based on BMO are important measurable parameters for glaucoma diagnosis. The accuracy of measuring these parameters is significantly affected by BMO detection. In this paper, we propose a method for automatically detecting BMO in SD-OCT volumes accurately to reduce the impact of the border tissue and vessel shadows. The method includes three stages: a coarse detection stage composed by retinal pigment epithelium layer segmentation, optic disc segmentation, and multi-modal registration; a fixed detection stage based on the U-net in which BMO detection is transformed into a region segmentation problem and an area bias component is proposed in the loss function; and a post-processing stage based on the consistency of results to remove outliers. Experimental results show that the proposed method outperforms previous methods and achieves a mean error of 42.38 μm.
Highlights
Glaucoma is an irreversible, progressive optic neuropathy that causes nerve fiber damage, visual loss, and even blindness [1, 2]
Bruch’s membrane opening (BMO) or neural canal opening, which remains stable with the progression of glaucoma, is an important biomarker in the optic nerve head (ONH) in Spectral-Domain Optical Coherence Tomography (SD-OCT) [5]
This method contains a coarse detection stage based on the retinal pigment epithelium (RPE) layer segmentation and disc segmentation in 2D projection images, a fixed detection stage based on U-net, and a post-processing stage to remove the outliers caused by the border tissue
Summary
Progressive optic neuropathy that causes nerve fiber damage, visual loss, and even blindness [1, 2]. Detection and treatment can slow the progression of the disease; identification of the structural changes in early glaucoma, such as cup-to-disc ratio and retinal nerve fiber layer (RNFL) thickness, is important [3, 4]. Bruch’s membrane opening (BMO) or neural canal opening, which remains stable with the progression of glaucoma, is an important biomarker in the optic nerve head (ONH) in Spectral-Domain Optical Coherence Tomography (SD-OCT) [5]. It is defined as the termination of the retinal pigment epithelium (RPE) layer. The disc margin can be identified by aligning the color fundus image and the SD-OCT volumes
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