Regio- and stereo-controlled synthesis of β-Xyl(1–4)Rbo-5P1-Rbo, the partial structure of O-mannosyl glycan

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O-mannosyl glycan is a pivotal glycan part of α-dystroglycan, which serves as a transmembrane linker connecting the intracellular cytoskeleton and extracellular matrix, such as laminin in skeletal muscle. We synthesized β-d-Xyl-(1–4)-d-Rbo-5P (1), β-d-Xyl-(1–4)-d-Rbo (2), and β-d-Xyl-(1–4)-d-Rbo-5P1-d-Rbo (3), partial structures of O-mannosyl glycan, in regio- and stereo-controlled manners, and demonstrated compatibility with the natural product.