Abstract
Background and aim: The relation between gastroesophageal reflux disease and Helicobacter pylori infection is controversial. The aim of this study was to investigate the relation between the presence of Helicobacter pylori and the histological and topografical features of Helicobacter pylori gastritis, and the severity of esophagitis. Material and methods: 129 patients (84 male and 45 female) with esophagitis diagnosed during upper gastrointestinal endoscopy were enrolled into the study. Ages of patients, gender, alcohol abuse and symptoms of reflux disease, medical history of surgery were also recorded. Los Angles classification was used for reflux esophagitis. Biopsies from antrum and the body of stomach were obtained. Sydney classification was used for gastritis. Results: Grade A esophagitis was found in 44,2% of all patients, grade B esophagitis in 46,5%, grade C esophagitis in 8.5% and grade D esophagitis in 0.8%. Total Helicobacter pylori rate was 73%, 68,2% in antrum and 68,2% in the body of stomach. There was no significant association between the presence, severity and distribution of Helicobacter pylori in antrum and the body of stomach and the severity of esophagitis. There was no significant association the presence of activation, inflamation, atrophy and intestinal metaplasia in both location and the severity of esophagitis. The rates of inflamation was similar in antrum and the body of stomach (%95.3 and %92.2). The rate of activation was significantly higher in antrum (66.7%) than in the body of stomach (47.3%). The rate of atrophy was significantly higher in antrum (58.1%) than in the body of stomach (24%). Conclusion: The frequency of Helicobacter pylori in patients with esophagitis was similar to the frequency reported in our country. Chronic active gastritis and chronic atrophic gastritis was more frequent in the antrun than in the body of stomach. These findings indicate that the types of histological gastritis caused by Helicobacter pylori rather than the presence of Helicobacter pylori is associated with esophagitis.
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