Abstract
The current widespread coronavirus pandemic has caused great concern and drawn research attention to the virus all over the world. The SARS-COV-2 spike glycoprotein, which binds to the human ACE2 receptor and mediates the membrane fusion and virus entry, is the main target for therapeutic antibodies. However, in recently resolved structures of the protein, some structural regions are still missing, for example, the hairpin repeat 2 (HR2) and the transmembrane C terminal domain (TMD), with the latter even lacking suitable modeling templates from its homologs.
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