Abstract
Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. The mean overall vessel surface area was 54.53 mm2 (range from 27.03 to 88.7 mm2). OCTA vessel surface area was slightly negatively correlated with age. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. No significant correlations were found for sex or between left and right eyes. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area.
Highlights
MethodsOCTA images and relevant ocular and systemic clinical data were recorded prospectively during a 24-month period, as part of a larger prospective OCTA trial (ClinicalTrials.gov, trial number NCT03422965)
The following summary statistics were calculated across all eyes for the independent variables, age, SE, AL, VA, and OCTA retinal vessel surface area: mean, standard deviation, minimum, 1st quartile, 2nd quartile, 3rd quartile, and maximum values
Summary statistics were calculated in Python v3.854 with pandas v1.155 and boxplots were generated in Python with Matplotlib v3.356
Summary
OCTA images and relevant ocular and systemic clinical data were recorded prospectively during a 24-month period, as part of a larger prospective OCTA trial (ClinicalTrials.gov, trial number NCT03422965). All data were captured between 4 and 6 pm This project was approved by the Institutional Review Board of the Hospital Clinic of Barcelona (HCB/2016/0216), and written informed consent was obtained from each subject. The relevant ocular clinical data that were collected included best-corrected visual acuity (BCVA), SE, slit-lamp biomicroscopy results, intraocular pressure measurements, retinal fundus examination results, and AL (IOL Master, Carl Zeiss Meditec, Dublin, CA). The collected systemic clinical data included age, sex, smoking status, systolic and diastolic blood pressure, height, weight, and body mass index (BMI). A comprehensive battery of OCT and OCTA images was captured using a Cirrus 5000 OCT device (Carl Zeiss Meditec, Dublin, CA). The current device has only a limited function for the removal of projection artifacts which is only possible in the overlays "Deep", "Avascular", "Choriocapillaris", "Choroid" and does not allow this modality for the export of raw data
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