Abstract
Background: Studies both invivo and invitro indicated anticancer and antitumor properties of saffron and its component against different human cancer cells which is wildly used as a drug to promote health and fight diseases from ancient time. Angiogenesis, formation of new blood vessels, is regulated by the balances of many stimulating and inhibiting factors. While physiological angiogenesis is under strike control, disruption of this control causes proliferation of a network of blood vessels penetrating into cancerous growth. One of the main factors which are involved in the process of angiogenesis in both physiologic and pathologic condition is VEGF-A. On the other hand, bio electromagnetic fields have been shown to be clinically beneficial in the mT amplitude range. The aim of this study was finding out if synergic effects of saffron aqueous extract and low-frequency electromagnetic field could decrease angiogenesis via reduction of VEGF-A gene expression.
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