Reduction in nitric oxide synthase activity with development of an epileptogenic focus induced by ferric chloride in the rat brain.

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Intracortical injection of iron ion has been shown to induce recurrent seizures and epileptic discharges in electrocorticograms. The importance of the effects of NO on seizure control systems and their regulation is suggested. In this paper, we examined the changes in nitric oxide synthase (NOS) activity in the epileptogenic focus induced by intracortical injection of iron ion at 5 min, 10 min, 1 h, 3 h and 3 days. Iron ion significantly decreased NOS activity in the cortex at the injection site 5 min, 3 h and 3 days after injection. These results suggest that the formation of an epileptic focus induced by iron ion is accompanied by decreased NOS activity.