Abstract
Pulmonary hypertension results in RV hypertrophy, fibrosis and impaired function resulting in RV failure. PH is associated with impaired heart metabolism and mitochondrial respiration. Mitochondrial supercomplexes (mSC) are assemblies of multiple electron transport chain (ETC) complexes that consist of physically associated complex I, III and IV to enhance respiration. We induced PH in rats by Sugen-Hypoxia (3 weeks) followed by normoxia (4 weeks). Control (n=11) and PH (n=10) were subjected to echocardiography, CN-PAGE to assess SC abundance and activity.
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