Abstract
BackgroundLesions of the angular gyrus (AnG) region of human parietal cortex do not cause amnesia, but appear to be associated with reduction in the ability to consciously experience the reliving of previous events. Objectives/HypothesisWe used continuous theta burst stimulation to test the hypothesis that the cognitive mechanism implicated in this memory deficit might be the integration of retrieved sensory event features into a coherent multimodal memory representation. MethodsHealthy volunteers received stimulation to AnG or a vertex control site after studying stimuli that each comprised a visual object embedded in a scene, with the name of the object presented auditorily. Participants were then asked to make memory judgments about the studied stimuli that involved recollection of single event features (visual or auditory), or required integration of event features within the same modality, or across modalities. ResultsParticipants' ability to retrieve context features from across multiple modalities was significantly reduced after AnG stimulation compared to stimulation of the vertex. This effect was observed only for the integration of cross-modal context features but not for integration of features within the same modality, and could not be accounted for by task difficulty as performance was matched across integration conditions following vertex stimulation. ConclusionThese results support the hypothesis that AnG is necessary for the multimodal integration of distributed cortical episodic features into a unified conscious representation that enables the experience of remembering.
Highlights
Growing evidence indicates that the angular gyrus (AnG) region of lateral parietal cortex is critical for subjective aspects of contextual recollection that draw on the conscious experience of reliving previous events
As the multimodal integration hypothesis predicts a specific reduction in cross-modal accuracy with within-modal accuracy unaffected, a “selective effect” ANOVA model was applied to the data [18], which confirmed the existence of a significant ordinal interaction, with AnG stimulation affecting cross-modal more than within-modal source accuracy, F(1,22) 1⁄4 5.813, p 1⁄4 0.025, hp2 1⁄4 0.209
Site of stimulation had no significant effect on source judgment RTs, t(22) < 1.463, p > 0.158, d < 0.142. This experiment investigated the multimodal integration of memory features as a putative information processing operation subserved by AnG that might underlie the conscious experience of reliving previous events
Summary
Growing evidence indicates that the angular gyrus (AnG) region of lateral parietal cortex is critical for subjective aspects of contextual recollection that draw on the conscious experience of reliving previous events. Results: Participants' ability to retrieve context features from across multiple modalities was significantly reduced after AnG stimulation compared to stimulation of the vertex. This effect was observed only for the integration of cross-modal context features but not for integration of features within the same modality, and could not be accounted for by task difficulty as performance was matched across integration conditions following vertex stimulation. Conclusion: These results support the hypothesis that AnG is necessary for the multimodal integration of distributed cortical episodic features into a unified conscious representation that enables the experience of remembering
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