Abstract
Symptomatic gastroesophageal reflux (GER) is commonly observed in patients with brain damage. This study evaluates the effect of acute and chronic brain injury on lower esophageal sphincter (LES) pressure in an attempt to determine a possible mechanism for GER in these cases. Adolescent (8 Ib) cats were anesthetized with pentobarbital (30 mg/kg). Baseline LES pressure was determined by conventional manometrics. Bilateral fronto-parietal cranial burr holes were made and an epidural intracranial pressure (ICP) monitor inserted in one side and a silastic balloon catheter in the other. ICP was increased by balloon inflation. LES pressure was measured acutely (at varying ICP's) and at 2 and 6 wk after the procedure. Mean pre-operative LES was 19.8±6.63 torr. At ICP of 20 torr, LES pressure was significantly reduced to 6.84 ( p p
Published Version
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