Reduced IGFBP-2 related immunoreactivity in human serum correlates with arterial stiffness in a healthy Chinese population.

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Circulating insulin-like growth factor binding protein 2 (IGFBP-2) is associated with metabolic changes in both physiological and pathological conditions. The aim of this study was to investigate the correlation between IGFBP-2 related immunoreactivity in serum and arterial stiffness in a healthy Chinese population. In this cross-sectional study, 360 healthy participants aged 37-87years were recruited from 1500 and were divided into three groups according to serum IGFBP-2 related immunoreactivity (Tertile I, 25.437ng/ml-120.870ng/ml; Tertile II, 120.871ng/ml-161.914ng/ml; Tertile III, 161.915ng/ml-321.636ng/ml). Arterial stiffness was evaluated by measuring the brachial-ankle pulse wave velocity (baPWV), ankle-brachial index (ABI), and carotid intima-media thickness (cIMT). The association between IGFBP-2 related immunoreactivity and arterial stiffness was estimated by multiple stepwise regression. Compared with the other two groups population, the individuals in Tertile I had significantly older age (62.66±13.30years, P<0.01), lower level of triglyceride (1.08±0.70mmol/l, P<0.01) and E/A (peak velocity of early filling and preak velocity of atrial filling ratio) (0.90±0.33, P<0.05). IGFBP-2 related immunoreactivity was inversely related with baPWV in the total population (r=-0.171, P<0.01) and in Tertile I (r=-0.275, P<0.01). After adjusting for age and the other confounders, no association was found between IGFBP-2 related immunoreactivity and baPWV in the total population. However, In Tertile I, reduced IGFBP-2 related immunoreactivity in serum was an independent risk factor of baPWV acceleration in three different adjustment models: Model 1 (no adjustment, P<0.01), Model 2 (adjusted for age, P<0.05), and Model 3 (adjusted for all variables, P<0.05). IGFBP-2 related immunoreactivity in serum is inversely associated with baPWV in a healthy Chinese population. This association did not change after adjustment for conventional risk factors for cardiovascular diseases in the subjects with the lowest IGFBP-2 related immunoreactivity. Consequently, reduction of IGFBP-2 related immunoreactivity may be a predictor of arterial stiffness. IGFBP-2 seems to be a potential intervention target in early atherosclerosis.