Redox-responsive MXene-SS-PEG nanomaterials for delivery of doxorubicin

Abstract

MXene has a large surface area, which gives medicinal drug molecules enough anchor sites. This property can be utilized to design incredibly effective intracellular drug delivery systems. In this work, a non-toxic and safe Ti3C2Tx materials was chosen in MXene. Ti3C2Tx MXene was decorated with Methoxy Polyethylene Glycol (PEG) by a linker cystamine dihydrochloride disulfide bonds (-SS-). The DOX delivery system of Ti3C2Tx MXene modified by PEG was constructed. To further examine the system's potential as a cancer treatment, in vitro tests were conducted. The outcomes demonstrated the potential of PEG-modified MXene nanosheets as nanocarriers for the delivery of DOX to tumors because they had excellent biocompatibility and no discernible side effects. In contrast to the free DOX, the drug carrier MXene-SS-PEG@DOX was more toxic to human hepatoma cells (HepG2) and less toxic to healthy macrophages (RAW264.7). DOX is released at a rate of 84.4% in PBS solution with a pH of 4.50 and a GSH concentration of 10 mM, which is higher than that of normal cells' physiological environment. The redox response drug delivery system has been investigated in this work, and the findings indicate that the drug delivery system is a promising contender for both drug delivery and stimulus response release.